Superbug breakthrough claimed
Australian researchers have discovered a way to find and beat superbugs, providing a critical breakthrough against many deadly infectious diseases.
A team from the University of South Australia has developed a miniature nanomedicine capable of carrying antibiotics into hard-to-reach infected cells.
The technology shows promise in successfully treating golden staph infections, which kill around 700,000 people globally each year, including 260 Australians.
The technique uses microscopic nanoparticles to carry an anti-tuberculosis drug into the cells of infected micro worms to kill hidden bacteria.
The experts expect the method to work just as well on urinary tract infections, bone and wound infections.
“Over time, bacteria have learnt how to hide in human cells, making some diseases resistant to antibiotics. To get around this challenge we have put the antibiotic into a very, very small vehicle that enables it to go into the body and kill the invading bacteria hiding in the cells,” Professor Clive Prestidge, from UniSA's School of Pharmacy and Medical Sciences and the Cancer Research Institute.
The nanoscale capsules containing the antibiotics are eaten by the infected cells, which then die at a much higher rate.
While human trials are a few years off, the researchers hope that because they are using approved antibiotics in a more effective and targeted way, this treatment could be saving lives soon.
“The time to take it from concept to human clinical trials to market is significantly reduced when we compare it with a new drug mode,” Prof Prestidge says.
“There are a number of technologies that are being developed to counter these superbugs. This is just one, but hopefully for humankind we are going to have a number of these coming into play over the coming years.”